Endocrine Abstracts

Fenretinide (4-hydroxyphenyl retinamide, 4-HPR) is a synthetic retinoid that exhibits anti-neoplastic properties and clinical trials indicate a potential chemopreventative action of 4HPR in the development of ovarian cancer. Although the mechanism of 4HPR action remains largely unknown, ceramide has been recently proposed as a cellular signal.The aim of the present study is to investigate in vitro the action of 4HPR and the retinoic acid receptor ...